Phase 1 clinical trial of Molnupiravir, a broad-spectrum antiviral

A rush for molnupiravir's approval could lead to disaster. Phase 1 and 2 trials of NHC in mice and ferret models infected with SARS-COV2 showed large improvements, and in human trials there was evidence of no viral load by day 5 of the trial. There were even very few acute toxicities listed. VLA2001 is currently undergoing a Phase I/II trial with 150 participants in the United Kingdom. [needs update] The trial was expected to be complete by 15 February 2021, with full reporting completed by August 2021. The trials are being supported by the UK National Institute for Health Research and four British universities. A recently published article described the safety, tolerability, and pharmacokinetic profile of molnupiravir (Painter et al. 2021), a novel antiviral agent with potent activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19). Here, we report an unprecedented collaboration between sponsor, contract research ... COVID-19 Exposé : First it was the Trump Administration along with the U.S.NIH or to be specific the NIAID headed by Anthony Fauci that poured millions of dollars in to the development and research of the overpriced drug remdesivir that is not only hepatoxic but also nephrotoxic to treat COVID-19. There are tons of studies that confirm its toxicity issues, these are just a few. Molnupiravir is a direct-acting oral, broad-spectrum antiviral agent in clinical development as a treatment for COVID-19. Ridgeback has completed Phase 1 and Phase 2 studies. Phase 2a trial evaluating the safety, tolerability, and antiviral efficacy of molnupiravir in the treatment of COVID-19 (ClinicalTrials.gov NCT04405570). Methods: Eligible participants included outpatients with confirmed SARS-CoV-2 infection and symptom onset within 7 days. Participants were randomized 1:1 to 200 mg molnupiravir or In brief, the phase three MOVe-OUT trial was an international randomized, blinded study that compared Molnupiravir to a placebo in non-hospitalized adults diagnosed with mild to moderate COVID-19. Background. In November 2020, the authorities ordered 26 million doses of vaccine from AstraZeneca, which reported 70% overall efficacy. It requires 2 doses of vaccine per person, so the quantity ordered would only cover 13 million people. Prayut cabinet later approved budget for ordering 35 million additional doses in January 2021. Siam Bioscience, a company owned by King Vajiralongkorn, will ...

2021.12.07 21:48 Dolosus19 Phase 1 clinical trial of Molnupiravir, a broad-spectrum antiviral

Phase 1 clinical trial of Molnupiravir, a broad-spectrum antiviral submitted by Dolosus19 to YoutubeScience [link] [comments]


2021.12.07 21:48 Investing_Walrus I'm afraid to hang out with my new friend because he's gay

I'm a second-year college student. Due largely to online classes (and just generally me sucking at being sociable), I've struggled to make friends.
A few weeks ago, this guy that sits behind me in one of my classes started making small talk before class. He's pretty nice, and we have some common interests, so he started inviting me to hangout, get lunch etc, and I'd say we're friends at this point.
The problem is, I'm afraid to hang out with him in public, and I feel awful for it. He's gay and, well... a bit flamboyant. Not deliberately, but he's very clearly gay.
I'm not homophobic. I'm gay. But I work hard to hide it. I'm in a somewhat conservative area, and have a very homophobic family. Despite students at my school identifying overwhelmingly as liberal, it's far from uncommon to hear people openly voice homophobic opinions and threats.
No one knows I'm gay. Despite this, a rumor went around that I was gay. I started getting looks, a few people made comments, and one evening, while I was walking alone at night, a group of guys heckled me. No one was around, and I was worried for my physical safety. It scared the crap out of me.
If any family found out, they'd kill me. 12-year-old me took a beating more than once because (long before I was having any sort of "thoughts") my parents thought I was gay.
No one at school had said anything for a while, but now that I've been hanging out with this guy we've started getting looks and people have begun saying things again. It scares me.
I don't want to be gay. I don't want anyone to find out I'm gay.
My friend has noticed that I've been acted nervous when out in public, and asked me about it. I can't tell him, that would be awful.
I don't know what to do. I'm scared. It feels like so much of my life is spent hiding or thinking about it now. It's exhausting.
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2021.12.07 21:48 Emergency_Dragonfly4 Microsoft word blows

I had auto save on and saved my document last night and somehow, as always, word corrupted the file and my work is lost.
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2021.12.07 21:48 BallDontNotLie Batista wants his 100 bucks. His slow burn against Triple H was fun.

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2021.12.07 21:48 Muter Best of /r/NewZealand Awards 2021 - Nominate and Vote here!

Well .. we thought 2020 was bad. After months of lockdowns, high tensions and ongoing bickering, 2021 is actually approaching year end. What a relief.
As usual, that means it's time to have a look back through the year and celebrate the best and worst of the subreddit in the last twelve months.
To kick things off, we've included some categories for awards below - please nominate people for those, or suggest your own category as a top-level reply!
Of course, we can't have a thread like this without ~~a power trip ~~ some ground rules:

Remember, you vote for the submission you want to win by upvoting that nomination comment. Comments on nomination comments don't count as votes! This thread will be in contest mode, so scores will be hidden and rankings randomised until voting closes. The voting period will run until about half way through January (let's say Saturday the 15th) and we'll announce the winners after that.
Good luck to all nominees, and from all of us on the mod team be sure to get a good break over the summer, relax, be safe, get some mental rest, don't drink and drive, enjoy the last few weeks of 2021 and we'll see you back in 2022 for the next adventure.
Ngā mihi,
The /NewZealand mods
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2021.12.07 21:48 SixteenTimesTheTodd Praise Todd Howard

Praise The Legendary Game Developer Todd Howard
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2021.12.07 21:48 16-Lines- 🔥 Englich Rap 🔥

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2021.12.07 21:48 anxious-american Crosspost from another sub

Crosspost from another sub submitted by anxious-american to antiwork [link] [comments]


2021.12.07 21:48 Far-Pay-58 🎙 Joe TV Episode 9 - Olympus DAO Co-founders Cryptofish & 0xMurloc host a Q&A session with @ohmzeus and @0xJala from the @OlympusDAO Team! Catch up on the chat here 👇

🎙 Joe TV Episode 9 - Olympus DAO Co-founders Cryptofish & 0xMurloc host a Q&A session with @ohmzeus and @0xJala from the @OlympusDAO Team! Catch up on the chat here 👇 submitted by Far-Pay-58 to CryptoGemDiscovery [link] [comments]


2021.12.07 21:48 godmobius [NG+7] [Lvl 302] [LtFV]

I need as many people as possible, we must jump this man. Currently in front of boss fog, I’ll set a password when you get here
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2021.12.07 21:48 without_my_remorse The market is now pricing in the first Fed rate hike in May 2022 and 3 hikes by the end of 2022.

The market is now pricing in the first Fed rate hike in May 2022 and 3 hikes by the end of 2022. submitted by without_my_remorse to atayls [link] [comments]


2021.12.07 21:48 kimberliahart Christmas Ball

Christmas Ball submitted by kimberliahart to painting [link] [comments]


2021.12.07 21:48 Prestigious-Mixture4 Knockout City Highlights - Let’s Go

Knockout City Highlights - Let’s Go submitted by Prestigious-Mixture4 to Gamer [link] [comments]


2021.12.07 21:48 jamfu123 Motor Mechanics in Australia

I'm thinking of moving myself and family to Australia. I'm not there yet but in the process of undergoing motor mechanics trade training with the British army and acquiring qualification September next year. I've seen that motor mechanics is on the skills shortage list. How would I be able to find an employer ? Is it better to do when taking a holiday there or is there an online job board were I can apply
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2021.12.07 21:48 TrendingBot [TRENDING] /r/confessions - Confess your secrets (+705 subscribers today; 217% trend score)

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2021.12.07 21:48 Dolosus19 Phase 1 clinical trial of Molnupiravir, a broad-spectrum antiviral

Hi Folks!
This is a video from my YouTube series summarizing scientific papers. These are meant to be easier to digest for non-specialist audiences to help make primary scientific articles more accessible to everyone.
I am excited to share my latest video! This is a summary of the paper: Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity against SARS-CoV-2.
It outlines the clinical trial data on monlupiravir, from Ridgeline therapeutics. These data show the safety profile and pharmacokinetics of molnupiravir for the first time in humans which indicate that it is safe for consumption.
Any thoughts on the video are greatly appreciated. I hope that you enjoy learning about this interesting topic!
https://youtu.be/bdrzeXIDB3c
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2021.12.07 21:48 AbbieDagrin Chris Hemsworth's Natal Chart

https://youtu.be/WuudGbusV_Y
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2021.12.07 21:48 pashotboshot Bertha Zúniga Cáceres on next steps in recovering democracy in Honduras after historic left victory

Bertha Zúniga Cáceres on next steps in recovering democracy in Honduras after historic left victory submitted by pashotboshot to socialism [link] [comments]


2021.12.07 21:48 miss_whatsherface Please help with this thank you!

Please help with this thank you! submitted by miss_whatsherface to Kaiheila [link] [comments]


2021.12.07 21:48 Uncultured_Nerd Does Ayanokouji *actually* study?

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2021.12.07 21:48 Humble-Association25 Boyfriend Trouble!! Help!!

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2021.12.07 21:48 Calvaaa Log In Que So Bad It Ends New Life

Log In Que So Bad It Ends New Life submitted by Calvaaa to ffxiv [link] [comments]


2021.12.07 21:48 DownVoteMeGently I really enjoyed the lighting in this picture.

I really enjoyed the lighting in this picture. submitted by DownVoteMeGently to pics [link] [comments]


2021.12.07 21:48 carl2k1 Hey guys, I got a free bike w/ trainer & car rack!

Hey guys, I got a free bike w/ trainer & car rack! submitted by carl2k1 to RedditPHCyclingClub [link] [comments]


2021.12.07 21:48 cutiepieslyfe roommate got a Maine Coon cat. I’m in love

roommate got a Maine Coon cat. I’m in love submitted by cutiepieslyfe to catpics [link] [comments]


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